Several commercial shops near the filling station have also been razed down by the fire which is said to have started during a discharge of gas by a tanker in the early hours of the day.
Though the Ghana News Agency cannot confirm the deaths, an eyewitness said three people, including a security man at the filling station received fatal burns during the explosion and they were rushed to the Komfo Anokye Teaching Hospital (KATH).
The filling station which is cited in the middle of a residential area, shares a fenced wall with a school, a church, a washing bay and several other commercial shops in an area between Krofoum and Tafo-Nhyiaeso.
When the GNA got to the scene, officers from the Ghana National Fire Service (GNFS) were still battling to douse the fire which had spread to some nearby shops.
Some residents told the GNA that this is the second fire explosion at the facility.
Mr Kwabena Nsenkyire, Ashanti Regional Co-ordinator of the National Disaster Management Organization (NADMO), told newsmen at the scene, that he has on several occasions warned shop owners around the area to move away since it was disaster prone area.He blamed the Kumasi Metropolitan Assembly (KMA) for not enforcing its byelaws which seeks ensure that